Thanks for the reply - there is ALOT of info on this case so was trying to keep it simple! This dog was adopted from TX as a feral puppy - is very fearful of people & is extremely dog aggressive although it lives with an older Golden Retriever. P - 70 at exam - my interpretation is too much parasympathetic tone as this dog's pupils were quite dilated and she was completely withdrawn/shut down at exam. Pulses were good - a little thin and wiry on the R, bounding on the L. Tongue color was light purple. The symptoms consist of variable appetite and training difficulties. She seemed to be doing better over the past few years, then became more picky about food about 3 months ago. She has been on a rotating diet of raw and some high quality dry foods. Her owners are both experiencing their own health problems. They live on a ranch in the mountains. She has noise phobia and is restless at night - she moves around a lot at all times. Reverse sneezing is frequent and severe, choking/coughing after drinking water, and belching happen often. She had a difficult time recovering from her spay anesthesia as well as recently when she had a liver biopsy performed.
Owner is a CVT - annual preventative blood work 4/14 revealed ALT 334, AST 61. U/S showed small nodules on spleen - otherwise N. DX - acute insult, put on RX Hepato Support. Recheck labs 6 weeks later showed ALT 542, AST 64. Added sAME, Vit. E, & Vetriscience Liver Chews - DX changed to chronic hepatitis. She was also getting acupuncture txs at this time. Changes made - increased the Hepato Support, added alpha lipoic acid, NAC and Xiao CHai Hu Tang. Recheck labs 7/14 ALT 802, AST 141.
Liver biopsy done - inconclusive (slightly atypical reactive lymphoid hyperplasia with low to moderate cellularity) but copper levels 1020.00 (IDEEX - paraffin block - N 120-400, toxic >1,500).
Owner has been in contact with Dr. Twedt at CSU but has concerns about conventional treatments. She is currently doing a protocol with Standard Process Livaplex, Zn Liver Chelate, and Hepatrophin PMG for 12 weeks with a recheck lab done at that time. She is currently doing a low copper diet and Lakota's appetite is a bit better. She continues to remain symptom free although associated behavioral signs with copper toxicity do include many of the anxieties this dog exhibits - info extrapolated from effects on people.
Thoughts? Does the above herb still fit? Thanks!