Question Details
Immune Mediated Thrombocytopenia In A Dog And Qing Ying Tang
by gryphon44 - November 12, 2020    View Case Report
13 yr old husky/collie mix. had a skin allergy issue start up that turned into an immune mediated thrombocytopenia. Her initial vet put her on pred and mycophenolate (her platelet count was at zero). Platelet count responded well on the meds but she did poorly on the meds and owners saw me wanting a euth. I took her off the mycophenolate and decreased the pred and she maintained for 2 months but then the owners tapered her too quickly off the pred (because altho she was feeling a bit better, she was still incont with panting and etc on the pred.) after 4 weeks off the pred she was at a 24 platelet count. I put her on qing ying tang BID and pred SID at 1.5 mg/kg. after 10 days she is 424 on platelets. My question is- if she stays on the qing ying tang, can I possibly wean her off the pred quicker? Currently the owners are ok with her quality of life, however she is still incont, pu/pd, panting etc on the pred. I am dropping her today to a 1mg/kg prednis once a day. (she's a 45 lb dog). Does anyone have experience using Qing Ying Tang for IMTP? I would like to get her off the pred, as I know the owners hate the side effects. I just dont want her to crash with her platelets.
Replies
by naturevet
November 13, 2020
Hi Jean!

Maybe to help hedge your bets, add one more formula to what you're doing: Chai Hu Jia Long Gu Mu Li Tang. The two formulas together are pretty formidable against blood dyscrasias. Either that or Si Miao San, if you have it, but CHJLGMLT is the stronger systemic immune modulator, so it is perhaps more likely to deliver, allowing you to wean off pred more quickly. For sure one of the two of them will help, but my money is on CHJLGMLT

At some point you should reach a threshold where the pred dose is low enough that there are no side effects, but one of those two formulas above will help reduce side effects if that is not the case and the dog is super-sensitive to the drug.

Eventually you should be able to come off the drug completely. I can think of one case over the years, though, that always required a ridiculously low dose of pred to have stable platelets. Still, it was at a level that never produced side effects. It was something like 5 mg every day, for the same size dog as you're dealing with. Hopefully (and very likely) you should be able to get to zero.

Please let us know how things go. You shouldn't have to go the euthanasia route here

Steve
by gryphon44
November 16, 2020
Thank you for your reply! I will add the CHJLMLT this week. and I will update how she does.
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