Question Details
Chronic Cough In A Dog
by jk176 - January 22, 2022    View Case Report
This dog has a very long history/problem list. This and the fact that I am a detailed oriented person has resulted in a very long post. Yikes/sorry/Thank you - Jennifer

14 year old f/s pyrenean shepherd
wt 22.8 lbs
history
6/24/20 - chronic cough, coughs after drinking, vestibular syndrome, 4/6 murmur, normal rhythm, lungs clear, severe dental calculus
cxr - cardiomegaly, left atrial enlargement, no evidence of CHF, diffuse bronchointerstial pulmonary pattern

7/11/20 - echo - myxomatous valve disease, severe LA and LV dilation stage B2
bp - 200 mmHg - very nervous
meds started - pimobendan 2.5 mg PO BID, enalapril 2.5 mg PO BID

7/25/20 BP 130 mmHg

10/2/20 - coughs after drinking still, appetite sl. reduced, pants all the time, energy not what it used to be
tongue dark lavender, pulse superficial toned

12/19/20 - maybe panitng a little less - does better in cold weather, drinking more, appetite sl. decreased, trouble
going down stairs
exam - lenticular sclerosis, iris atrophy, heavy calculus/halitosis, iris arophy, 3/6 murmur, normal rhythm/rate, lungs clear, resents hip extension/decreased rom
soft sc mass left thorax - lipoma
tongue pink to red, pulse - strong, very toned/snappy

10/8/21 - coughing increased coughs up white phelgm occasionally, panting a lot, confusion worse, eyesight and hearing seems worse
PE - eyes/teeth as noted, 4/6 murmur, occasional abnormal rhythm, tiny adenoma with scales right pinna
tongue dark lavender with phlegm, pulse - toned, strong, mid depth, sl. fast
pea sized left anal sac nodule - fna - anal sac adenocarcinoma
cxr - moderate to severe cardiomegaly with left sided CHF
ECG - sinus rhythm with intermittent single APCs
Rx furosemide 20 mg PO BID

10/30/21 - great appetite, PU/PD, seems overall better, coughing a little more
pulse - toned, strong, fast, superficial, tongue big, lavender body, red tip

echo - myxomatous valve disease, severe LA/LV enlargement stage C
cxr - moderate tracheal collapse, replapsed cardiogenic edema, sl. hepatomegaly - liver included in rads
increased furosemide to 30 mg PO BID, prescrivbed hycodan 2.5 ml PO BID or as needed

recommended Nat Path modified xue fu zhu yu tang - shared the formula with Pan's owner who is a human acupuncturist and chinese herbalist -

she looked at the formula and recommended using xue fu zhu yu tang with 7 grams of Fu Zi and 5 grams of Gan Jiang. I went with this, but in restrospect this seems like it will
make it too warming. I will share her e-mail.

11/13/21 abdominal ultrasound to stage anal sac cancer - liver - hyperechoic lesions - non specific, kidneys - possible early renal disease, pancreas sl. heterogenous

1/14/22 - dry harsher cough increased in frequency, increased appetite, drinks alot especially after pimobendan, gets agitated at 5-8 pm, wants to go outside, likes to play
outside in the snow
PE - 5/6 murmur, arrhythmia, lungs clear, anal sac nodule sl. increased in size, sl. dull coat
tongue - dark/lavender to reddish, big/hangs out of mouth/over teeth, mild phlegm
pulse - toned, fast, strong, superficial
ECG - atrial fibrillation
superchem/cbc/t4 - ALP 166 (5-131) - was 174 on 10/8/21
BUN 37 (6-31) was 32 on 10/8/12
Calcium 12 (8.9-11.4) was 11.6 on 10/8/21 - had been elevated prior to anal sac nodule's appearance, but this may be causing the increase
platelets 644 (170-400)

Rx diliazem 15 mg PO TID
cxr scheduled

A - qi/blood stagnation chest - cough, cardiac disease, arrhythmia, tongue, pulse
damp/ phlegm/stagnation anal sac nodule, phlegm on tongue, lipoma, adenoma
agitated in the evening - heat/yin deficiency/triple burner obstruction
excellent appetite - heat/yin def/damp
PU/PD - heat/yin def
increased platelets - triple burner obstruction
vestibular episode - triple burner obstruciton

It seems some version of XCHT would be a good fit for her as would the Nat Path modified XFZYT.

What do you think?

questions - what are the TCVM DDX for arrhythmias - stagnation, qi deficiency?

HERE is the e-mail from Pan's Mom a human acupuncturist/herbalist:

Xue Fu Zhu Yu Tang is a good formula.
The theory looks like it is from the Traditional Chinese Medicine (TCM) Angle. All good.
And from the veterinary angle, that is your department.
What I can offer is an add from the Classical Medicine lineage.

Here is how I would assess the herbs via Classical Chinese Medicine - I practice both TCM and Classical. Apologies for the long winded explanation.

Tao Ren - a heavy duty blood mover, not as heavy as like an E Zhu

Dang Gui Shen moves, moistens, and warms - the primary blood herb, it does moisten the stool (not too much), but has that function, warming the blood alone can often help it move an if there is ‘crappy blood’ (too dry, stasis, or too cold or hot)

Hong Hua is a flower that means it’s direction is up and out so it helps spread the blood

Sheng Di huang - can be cloying hard to process but with Chuan Xiong and Chi Shao it can tonify and move, blood nourishing, to move the blood, there needs to be enough good blood to move

Bai Shao is fantastic for bringing water back into the blood and getting fluid where it should go - different from a diuretic method of moving fluids, different from just adding translucent moistening herbs but by bringing what is described as water that separates from the blood back into the blood. It is often described as getting the fluid that is not where it should be and getting it back in right relationship. That improves the quality of the blood, which is the goal. It changes a pathological substance into a physiological one ie makes it useful.

Chi Shao - similar to Bai Shao - it is red vs white and is more moving and has less of a function of absorbing but still has some

Chai Hu is a popular Liver Herb (store/release blood), which helps open the Shao Yang pivot - if the pivot is not open it will keep fluid backed up and headed back to the heart and lung, critical to keep that open

Huai Niu Xi also directs the blood downward to the lower body -

Jie Geng is an excellent choice, like Bai Shao it is a chalky herb that helps absorb fluid, and goes to the lung, aids the cough, also helps with phlegm which is translated in this case as fluid congestion in the lung or an accumulation of phlegm that can create a nodule possibly blocking the anal gland

Zhi Ke is an earth herb that along with Chai Hu helps get the fluid to move down, aids the yang energy from above - yang is the force moving the yin substance, so this is critical in getting proper digestive function which is often where fluid and dampness or blockage arise

Gan Cao is a harmonizer of all the flavors of the herbs to make them all function at their best, it actually generates fluids (steroidal quality0

The one missing item is a Rou Gui (Cinnamon Bark) or a Fu Zi (aconite) -something to build the fire below to heat the moisture to steam it up and out to moisten lung and to cool the heart fire.
With Gan Ca, these 3 herbs are great for anchoring the yang below the yin in Shao Yin (ministerial Fire).
Shao yin is Ki/Ht the place our yang from heaven roots below - it is the fire that warms us and births the yin which is the substance that nourishes the digestion Tai Yin (Lu/Sp) and Jue Yin (Lv/Pericardium).
This process allows the three yin to properly function. Once out of the 3 Yang conformations and into the 3 Yin conformations it is a later disease condition. Shao yin regulates the water and fire, aids the Tai yin the metal and earth in digestion and together they create fabulous blood which is jue yin (ministerial fire, Wood).

Xue Fu Zhu Yu Tang all about moving blood, and a small amount of nourishing.
The fire below that can get Pan’s root re connected is still to be addressed.
That said, formulas for pets are premade, I imagine, so there is little chance to tweak a formula.
Go with this formula and we can see what shows up.
Maybe there is a formula you have in you book with Rou Gui, Fu Zi, Gan Jiang, Gan Cao - Might be called a Si Ni Tang.
If there is we could try adding that after this - either alternate it as an add, or alongside it.
Replies
by naturevet
January 28, 2022
Hi there,

That is a long post, indeed! I do agree that this dog is a Shao Yang disharmony case, and adding Minor Bupleurum in with Xue Fu Zhu Yu Tang (without the acupuncturist's modifications) will probably materially help this dog.

As for the addition of heating herbs by the acupuncturist, I'm not sure where she got those. Xue Fu Zhu Yu Tang is a Classical formula in and of itself. It never did have heating herbs and dates back to the 1800s. As a Shao Yang case, the dog's Yang energy is pent up. Adding more Yang through heating herbs does not help it, in my view.

Hopefully these comments help you out! Again, by adding Xiao Chai Hu Tang and changing Xue Fu Zhu Yu Tang to just the modification containing San Leng and E Zhu, you should have a good chance of stabilizing the dog's heart and combating the tumor. If the heart stabilizes, they can consider a dentistry to remove the bacteremia that might be aggravating or accelerating valvular decline

Good luck!

Steve
by jk176
January 29, 2022
Hi Steve,

Thank you so much for wading through all of the information and clarifying it for me. I really appreciate it. I will pass long your input.


Jennifer
by jk176
March 19, 2022
Hi Steve,
I have an update on Panteleimon. Should I enter the information anywhere else?

She is doing better. She is having less coughing episodes. She had one episode at home 2 weeks ago during which she was wheezing and had trouble breathing. She is sleepier during the first part of the day and drinks and urinates more during the second part of the day - large amounts and more frequently. Her appetite is fine and her weight is stable.

Exam:
pulse - toned/fast/narrow/superficial/strongish
Tongue - tip pink, body big, pale lavender, not dry or moist - major change from the last visits - when it had been dark lavender
4/6 murmur, normal rate/rhythm, lungs clear
HR 132
RR 32
dry cough when picked up
much less dyspneic/coughing then during past exams
feet/ears sl. cool, back sl. warm
tense/distended abdomen as in the past
left anal sac nodule sl. increased in size
no change in pulse with acupuncture points GB41/ST41, LIV3

BUN/creatinine increased
BUN 75 (on 3/19/22) 58( on 2/18/22)
Creat 1.8(on 3/19/22) 1.5 (on 2/18/22)

2/18/22 cxr/ecg - improved supraventricular tachycardia with occasional vpcs, severe cardiomegaly with
resolved pulmonary edema

Current meds: diltiazem 22.5 mg PO TID, spironolactone 25 mg PO SID, furosemide 40 mg am, 30 mg mid-day, 40 mg pm ( this to this dose on 2/4/22), pimobendan 2.5 mg PO BID, enalapril 2.5 mg PO BID

The cardiologist recommended discontinuing the enalapril today. 3/19/22

current Chinese Medicine: Nat Path Xiao Chai Hu Tang 0.5 tsp PO BID, modified Xue Fu Zhu Yu Tang 0.5 tsp BID

Overall, she is doing better. I am concerned about her kidneys and her pale/big/lavender tongue and increased renal values. Do you think she needs a kidney qi or would that be too warming? Her pulse doesn't really fit this, though.

Thank you for your help,
Jennifer
by jk176
March 19, 2022
Hi Steve,
I have an update on Panteleimon. Should I enter the information anywhere else?

She is doing better. She is having less coughing episodes. She had one episode at home 2 weeks ago during which she was wheezing and had trouble breathing. She is sleepier during the first part of the day and drinks and urinates more during the second part of the day - large amounts and more frequently. Her appetite is fine and her weight is stable.

Exam:
pulse - toned/fast/narrow/superficial/strongish
Tongue - tip pink, body big, pale lavender, not dry or moist - major change from the last visits - when it had been dark lavender
4/6 murmur, normal rate/rhythm, lungs clear
HR 132
RR 32
dry cough when picked up
much less dyspneic/coughing then during past exams
feet/ears sl. cool, back sl. warm
tense/distended abdomen as in the past
left anal sac nodule sl. increased in size
no change in pulse with acupuncture points GB41/ST41, LIV3

BUN/creatinine increased
BUN 75 (on 3/19/22) 58( on 2/18/22)
Creat 1.8(on 3/19/22) 1.5 (on 2/18/22)

2/18/22 cxr/ecg - improved supraventricular tachycardia with occasional vpcs, severe cardiomegaly with
resolved pulmonary edema

Current meds: diltiazem 22.5 mg PO TID, spironolactone 25 mg PO SID, furosemide 40 mg am, 30 mg mid-day, 40 mg pm ( this to this dose on 2/4/22), pimobendan 2.5 mg PO BID, enalapril 2.5 mg PO BID

The cardiologist recommended discontinuing the enalapril today. 3/19/22

current Chinese Medicine: Nat Path Xiao Chai Hu Tang 0.5 tsp PO BID, modified Xue Fu Zhu Yu Tang 0.5 tsp BID

Overall, she is doing better. I am concerned about her kidneys and her pale/big/lavender tongue and increased renal values. Do you think she needs a kidney qi or would that be too warming? Her pulse doesn't really fit this, though.

Thank you for your help,
Jennifer
by naturevet
March 19, 2022
Hi there

I'd be tempted to try continuing the Modified XFZYT, but changing the XCHT out for now and replacing it with Ba Wei Di Huang Wan (Rehmannia Eight Combination). That formula fits the tongue, can aid cardiac complaints, and supports renal blood flow

Give it a couple of weeks and then recheck. If renal parameters are improved, and cardiac signs are stable or improving, then I think you've found your protocol
by jk176
April 9, 2022
Hi Steve,

Thank you for this. So I spoke with the cardiologist about the azotemia and he recommended discontinuing the enalapril which we did on 3/19/22. Due to a communication break down, Pan stayed on her original Chinese herbal formulas and didn't start BWDHW.

She has been on a commercial whole food diet - Farmer's dog - for about a month.
She came in yesterday for a recheck. Overall she is holding steady, her cough is about the same, her panting is much less, her appetite is great. She had diarrhea 2 nights in a row. She is waking up to urinate multiple times a night.

PE - BAR, less panting/coughing during the exam, murmur 4/6, arrythemia resolved, hr 156, lungs clear, abdomen tense, distended, no palpable masses, left anal gland tumor has increased in size,
Tongue - dark lavender with pale sides and caudal body, big, pulses toned, fast, stronger, moderate depth

BUN still elevated from 68, (was 78), creat 1.6 (was 1.8)
HCT stable at 46, total calcium still elevated at 12.2

It seems like her pattern still supports the use of XCHT and modified XFZYT, but there may be some liver blood deficiency and spleen qi deficiency and kidney yin or qi deficiency.

Can I start her on BWDHW in addition to the other formulas? Or is there a better option?

Thank you,
Jennifer
Reply to this question.
You must be logged in to reply