Question Details
Chronic Cough In A Cat
by jenmercier - April 13, 2024    View Case Report
Spritzi
10 yo FS DSH orange tabby, ~11 pounds, BCS 4.5/9

Chief complaint and associated histories:
- Chronic cough- has had a cough starting at 8 mo old.
o Responded immediately to prednisolone (after conventional med work up to dx feline asthma).
o Each time I tapered the pred, the cough would return.
o Did not respond to Bu Fei San, partial improvement with Lily combination (Jing Tang), and most improvement with Breathe Easier B (Jing Tang). Still dependent on fluticasone inhaler daily.
o Cough spells are infrequent and non-productive. Sound a bit raspy/phlegmy. She also sounds wet rattly in the morning when purring and swallowing now. (Damp)
- Vomiting food in the morning immediately after eating or during eating.
o This started at about 4 yo and was sporadic. Gradual increase in frequency. With a few exceptions later on, she did not seem to be bothered by it and kept food down the second try and usually not long after the vomiting event
o Eventually she had a bout of nausea associated with it and occasionally constipation seemed to play a roll.
o A couple of events of gastritis led to an ultrasound that identified a gastric ulcer
o The gastric ulcer was tx with conventional medicine (sucralfate, ondansetron, omeprazole) and symptoms greatly improved. (HEAT)
o Fluticasone inhaler was d/c and oral prednisolone was begun to tx both asthma and IBD/gastritis.
o At the same time, Si Miao San was started with what appeared to be good success but the morning vomiting of food returned intermittently.
o After discussion with Dr. Marsden at a conference, Si Miao San was switched to Three Seeds.
o She has been taking Three seeds for several months with only occasional vomiting. The prednisolone was tapered to low dose daily (1.25mg). (DAMP)
o Attempt to taper to EOD low dose prednisolone has led to a return of the cough. Very infrequent and she has never had dyspnea associated with the asthma but it is evidence to me that the pulmonary inflammation is present.

General history:
- Good appetite now, has been a struggle in the past
- No PU/PD
- Stools have always been on the dry side. Better now but still probably not ideal moisture (Excess Heat vs Yin deficiency)
- She had gingivitis as a kitten and now has what I would consider normal periodontal disease given her age (no stomatitis) (Excess Heat vs Yin deficiency)
- She has vigorous dreaming often now (Blood deficiency?)
- She is having hesitancy jumping but still makes it after a bit of wind up (Kidney deficiency)
- Did not appreciate side effects to steroids at any dosing.
- She hates acupuncture and will not allow me to do it!
- She does not prefer cool; glues herself to the heating vents in the winter; has always loved the sun spots and heating vents!
- Can be needy and clingy; Loves to be brushed
- She can be feisty too; gets along with younger cat in house but doesn’t know how to play nice and can get jealous
- Certain situations and people frighten her into panic but in general she will greet visitors and is curious

Physical exam
- Tongue- sometimes light to pale pink, other times red, generally moisture and size seem normal, edges are slightly rounded (not thin)
- Pulse-
o very difficult to find, deep, narrow and felt rounded with a bit of tone
o rate is normal to slightly fast
o I appreciated an irregularity in rhythm with palpation but auscultation was regular, no murmur
- Not able to palpate for active points

Medications/supplements
- Prednisolone 1.25mg daily
- Omega 3 fish oil capsule- 2 days on/1 day off
- Doc Silver chew (CBD/mushroom blend)- 1 EOD
- Three Seeds (Kan)- 1 tab BID

Diet: (obviously not ideal but she is stubborn and has refused fresh foods)
- 1/8 cup kibble (Hill’s GI Biome and adult maintenance corn/soy/wheat free)
- 1 can variety of wet food split into two meals (3.5oz)
- She will not eat fresh cooked meat except she loves salmon sushi
- She goes nuts for crackers, chips, etc. maybe it’s the salt content?

Questions:
1. Vomiting seems much improved with Three Seeds but now as I try to taper the pred, her cough is returning. Should I keep her on this formula and add a second? Is it safe to keep her on Three Seeds long term if so?
2. I am not sure of the diagnosis for the cough? Nor how it relates to the vomiting.
a. Responds to pred- implies Heat and dryness/yin deficiency
b. Responded best to Breathe Easier B herbal in past- Kidney (Jing) deficiency not grasping the Lung Qi
c. Maybe started as Heat (cough, gingitivitis, dry stool as a kitten) and was root of it all. Vomiting and Damp Heat progressed later in her life
d. Does she have signs of blood deficiency (intermittent pale tongue, vigorous dreaming). Is that playing a role here?
3. How should I adjust her herbs? Just based on her response to pred, seems like I need a cooling, moistening formula for her lungs but Damp draining for the Stomach. And possibly blood tonic?
Replies
by naturevet
April 27, 2024
Hi Jen,

I'm with you in your assessment ideas. Dampness is clearly present. Specifically, Phlegm is obstructing the descent of Stomach and Lung Qi. It's just the next step that is unclear, so we can stop the coughing.

In a cat on processed food, we probably need to be careful with Yin tonics, especially given the lack of response to the two lung tonic formulas from Jing Tang. Blood tonification should be indirect for now, by supporting the Spleen and Stomach, so they don't manufacture Dampness, but Blood and Yin instead. The success of pred can suggest Blood and Yin deficiency, but it's more compelling if tiny doses of pred every few days were enough to resolve the issue. Still, pred responsiveness can suggest an adrenal or Kidney issue. The success of the Breathe Easier formula likewise suggests that there is Kidney (Yang) deficiency as well as a failure of Lung Qi to descend, since that was chiefly how it differed.

Putting all that together, I'd wonder if:
- there was a primary Kidney deficiency, even from an early age
- the lack of Kidney Qi led to a lack of Spleen Qi. This, in turn, leads to Dampness accumulation, and slow development of Yin and Blood deficiency
- Kidney Qi deficiency can also lead to an impaired ability of the Kidneys to reach up and grasp descending Lung Qi
To safely probe that concept, I'd try adding in Rehmannia Eight, which actually pairs quite well with Three Seeds (though often for the purposes of treating renal azotemia. Still, a good pairing is a good pairing!). It tonifies Blood and Yin using Rehmannia, but is warming to the Kidneys and drains Damp. It ticks a lot of boxes and is actually my favourite formula for asthmatic cats. I'd probably try it here next and it should be safe.

Let us know how it goes if you give it a try!

Steve
by jenmercier
May 2, 2024
Amazing! Cannot thank you enough. It gives me a bit of confidence because I have been thinking for years that Kidney deficiency was present from the start.
She is getting Kan Essentials Three Seeds tablets- 1 twice daily. Would you pair that with Rehmannia 8 1 tab twice daily for dosing?
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