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6yr FS Mastiff With Aggressive MCT

by lrf9187 - April 9, 2025

Hi!

Posting a sad but interesting case. Fingers crossed that I get some progress.

6yr FS Mastiff (looks like she's part Boxer...) with a high gr/Gr 3 MCT on her caudal thigh. Quickly recurred after complete excision with narrow margins despite pred 1mg/kg/d. The incision is not healing and new masses (large, firm, erythematous, inflamed) have developed on the caudal aspect of it. There's also spread to the local lymph node and post-FNA that area now has a large erythematous mass present as well. It's all terrible-looking. Splenic FNA was negative.

T: Purple
P: deep/weak/narrow but toned

I'm putting her on fresh food (was on Purina), XFHMY, antioxidants, marshmallow/milk thistle/albizia/turmeric/licorice, fish oil and Vit D (pending Vit D levels). She's also on Benadryl & gabapentin.

I just submitted this question to Dr Bannink, so I'll see what she says: The oncologist recommended against Palladia due to the non-healing wound. Is this contraindicated? It seems like it won't heal anyway if it's not healing because it's cancer tissue... Owners don't want to pursue Vinblastine, but would pursue Palladia in combination with the above.

Second easy question- any particular antioxidants you recommend or things to look for in antioxidants?

by naturevet

April 14, 2025

Hi there!

Sorry about the delayed reply here. Hopefully it is still useful. I don't have any particular antioxidants to recommend. There are so many. I know there are some (expensive) ones developed by vets ostensibly to treat cancer, but I don't have a lot of experience with them, and have never heard of them saving the day.

XFHMY was a good call. We need to be careful in how much we mobilize Blood in a rapidly metastasizing tumor, but the tongue does corroborate the diagnosis of Blood Stasis. The tongue suggests a certain amount of Yin damage. For metastatic tumors in humans with this kind of presentation (Stasis, Heat, damaged Blood or Yin), I've been using Blood movers (like XFHMY) with Qing Ying Tang and also Xiao Chai Hu Tang to which I've added 25g of Qing Hao. I would suggest giving that a try. Hoxsey is fine to add in there, too. I know it's a lot, but to get control of runaway tumors, you need to use large amounts of herbs. A fresh food diet is important as well.

Hopefully this helps you out. The other tack is to try a Wei Qi tonic for a non-healing wound, but it can easily exacerbate inflammation, which allows the tumors to spread faster, so I would try the above approach first, which at least has little chance of making the situation worse.

Fingers crossed you see some stabilization at least

Steve

by lrf9187

May 1, 2025

Thanks, Steve! Unfortunately it was already so far along already even when I saw them, within a week of starting the above protocol they opted for euthanasia :(

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