Question Details
Thymoma Complications
by bannink - May 11, 2009
Hi Steve,

Looking for some advice on a thymoma patient who came to me with many complications. Here goes:

11yo FS Shih Tzu diagnosed elsewhere in Jan 09 with thymoma (dyspnea, pleural effusion, mass). Also mature lymphocytosis at that time (28,000; normal 690-4500) presumed chronic lymphocytic leukemia or severe antigenic stimulation due to cancer. Underwent full course Radiation resulting in ~50% tumor shrinkage. Post-radiation thoracotomy for resection resulted in severing left phrenic nerve. Resection was aborted after apparently 3 arrests. She, remarkably, lived and acts relatively normal. Post-op very poor appetite, intermittent diarrhea (cowpie, slight mucus, no tenesmus) and occasional vomiting, bradycardia/ severely pronounced sinus pauses presumably due to increased vagal tone and severed phrenic nerve, "exaggerated"/somewhat erratic breathing pattern (both inspiratory and expiratory but more pronounced irregularity on inspiration). No real improvement in appetite with mirtazapine. On gabapentin for post-op pain. Extreme lethargy and inappetance with tiny dose of tramadol. She has always been a picky eater but no other previous health problems. Pulse thin, deep and weak. Tongue pale and small. Active points BL 20, 21 +/- ST 36 and BL 15. Went berzerk when I needled PC 6 so I didn't. Dx: Qi deficiency (SP--> LU +/- HT) +/- blood deficiency. Prescribed Liu Jun Zi Tang to tonify SP and ST Qi (major complaint was poor appetite/V/D with mucus). Response: only mild improvement in appetite. Vomiting and diarrhea resolved. New problem: episodic ataxia and collapse. Echo normal, ECG shows severely prolonged sinus pauses most pronounced in left lateral recumbency (side of phrenic nerve damage). She is basically fainting sporadically and not necessarily with exertion - at the clinic she was just wandering calmly around the exam room. She continues to be lethargic and her appetite poor. The owner was having trouble giving the powder so I had her switch to tincture. No improvement. While I was gone she got started on prednisone which has helped a little with appetite but her breathing is now very labored.

I am still thinking underlying SP Qi def --> LU Qi def, maybe blood loss during sx-->HT Qi/Yang def. The thymoma is stable. Major complaints now are respiratory difficulty, poor appetite and fainting episodes. Vomiting and diarrhea have resolved. She is still a little chilly (trembles).

I can't really find a formula that seems to fit all these things great. What do you think of Bu Zhong Yi Qi Tang at this juncture? Can I think of this hemiparesis of the diaphragm as a kind of organ prolapse? Is there something better to tonify the Qi and Blood in this patient? Something to better address the fainting and respiratory signs that also addresses appetite?

Thanks a million!

Erin
Replies
by naturevet
May 11, 2009
Now that you're a boarded oncologist, do you miss nail trims and ear cleans some days? Boy, you get some tough cases.

Anyway, I agree completely with the diagnosis of Qi deficiency, bordering on Qi collapse. The question is, where is it coming from? The dyspnea and tumor imply a severe stasis in the chest. Blood stasis in the upper burner can certainly do that, but when collapse is involved, I also think of a TB obstruction. The TB is the origin of Source Qi, so an obstruction there leads to Source Qi deficiency. if in doubt, we can even treat with two formulas instead of one. I'd go with Xue Fu Zhu Yu Tang and Xiao Chai Hu Tang together; or at least the latter. Definitely XCHT addresses the concerns of collapse, loss of appetite, dyspnea, and tumor development. XFZYT may be a little rich for her yet, if she is so recently Spleen Qi deficient.

As for the diaphragm, if anything, the prolapse would be upwards, not downwards, right? On inhalation, the diaphragm would get pulled cranially and reduce the volume of the chest. XCHT is a bronchodilator, and so may cut the amount of negative pressure needed to generate inhalation, such that the diaphragm doesn't displace as much. Even a regular bronchodilator may help there.

So hopefully that helps. It's the first thing I'd try, anyway!

Steve
by bannink
May 12, 2009
Thanks Steve,

I'll let you know how it goes. XCHT did not even cross my mind in this case, but I can see the argument for SJ obstruction. I was assuming a stasis tumor but with how deficient this dog is I was reluctant to do XFZYT yet. Thanks for the suggestions and the pathophysiology lesson!

Erin
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