Question Details
Hepatic Fibrosis In A Dog
by jlrenton@shaw.ca - October 24, 2014    View Case Report
Trekker is an 8 year old Lab/Retriever male neutered. I saw him initially in October of 2013 because routine blood work revealed elevated hepatic enzymes and bile acids (pre and postprandial). At that time an ultrasound showed a small liver. Trekker's owner called me because she is interested in alternative therapies. At the time of this visit, Trekker was feeling well. His regular veterinarian had recommended a prescription liver diet (processed dry) and sAme, milk thistle and vitamin E.
I found Trekker to be sociable and highly energetic, with the ability to settle. The owner reported dreaming once daily, a preference for warmth, normal thirst, firm long stools, and good with people but occasionally growly with other dogs. Trekker loves to track and is focussed when doing so. The owner reported that Trekker fears wind and spends the winters with her in Mexico. His heart rate was 90/minute, he was in lean condition, tongue dark purplish, pulses wiry. He was warm over BL18, LIV 13 and GB 24. I needled those points and some other empirical points for liver disease, but noted little difference in the pulse. I discussed the benefits of whole food rather than a processed prescription diet.
I saw Trekker again in April 2014 when he returned from Mexico. He had good energy, heart rate was 90/minute, tongue lavender and pulses wiry; he had lost weight. Repeat blood work showed ALP 2246 (21-122), ALT 571 (10-113) and GGT 73 (1-18), Pre-bile acids were 27.7 (0-15) and post 123.4 (0-22). The owner proceeded with a liver biopsy late in the summer that indicated 40% hepatic fibrosis.
In August I saw Trekker; he had remarkable ascites, was thin, eating poorly and had decreased energy. He was panting and restless and seeking cool. His regular veterinarian had prescribed prednisone, spironolactone, milk thistle, vitamin E, ursodiol, omeprazole, sucralate and a prescription hepatic diet (that Trekker would not eat). Tongue was pale lavender, pulses slippery and wiry, and there was warmth over BL 18. He had collarettes and some active areas of moist superficial dermatitis on his left ventrolateral abdomen that he was licking obsessively. I needled BL 18, 20, 22 (pulse worse with 22 so removed), ST 36, SP 6, 9, CV 4, 5, 6, LIv 3 and LI 4. I asked a human TCM doctor for some herb advice and he prepared a formula of Ci wu jia, Huang qi, Yu Jin, Chai hu, Dan Shen, Zhi mu, Huang bai that was begun August 27. The first week of September, Trekker's enzymes had improved except for the ALT which had worsened. He was beginning to eat well (whole food, including liver) and was feeling better. September 5 he had most of the abdominal fluid removed and it has not returned. His albumen is normal.
On September 30 I started him on Xiao Yao San, and saw him again on October 17. The skin lesions on his side had healed and left numerous scars, and a new area had become bothersome at the costochondral junction of his 10th left rib. No other areas of his skin were affected. He was eating well, had normal energy and had gained weight.
He is currently on prednisone 5 mg daily, ursodiol, sAme, milk thistle, vitamin E and Rambling Ease. I appreciate any further advice.
Thank you in advance.
Replies
by naturevet
October 27, 2014
Hi Janet,

The formula you used prior to Xiao Yao San has a very similar effect, in that it both tonifies and moves. That formula was probably directed more to something like Hepatitis C in humans, and Xiao Yao San is potentially a better choice for small animals.

Unless the improvements don't continue, Xiao Yao San is thus not a bad formula to continue with. It's how I complete treatment for a lot of liver cases, and contains herbs that are specifically known to inhibit fibrosis and progression to cirrhosis. Unless something happens to derail progress, or improvements stall out, I'd give it a try.

Congratulations on your success thus far with such a challenging case!

Steve
by jlrenton@shaw.ca
October 27, 2014
Thank you Steve,
I am wondering if you have a theory about why Trekker is bothering his left ventrolateral thorax and abdomen, and if so whether there is anything I could try to resolve this.
Janet
by naturevet
October 27, 2014
Ventral lesions indicate Damp Heat, generally. To address this while still promoting enhanced liver circulation, you could look at Chu Shi Wei Ling Tang, in addition or instead of Xiao Yao San. I wouldn't stop the latter, though, if liver improvements are continuing

Steve
by jlrenton@shaw.ca
October 30, 2014
Thank you again. I will let you know how Trekker is progressing.
Janet
by jlrenton@shaw.ca
November 27, 2014
Hi Steve,
Trekker is still feeling well, and has gained some weight. His albumen, however, has decreased and his bilirubin has increased again. ALT, ALP, GGT and bile acids pre and post-prandial have increased as well. He has begun to chew on his right thigh in the region of GB31 and has formed a 5 cm ulcerated lesion there. The rest of his coat looks healthy. His tongue is dark pink and pulses slightly wiry.
Is it possible that the Xiao Yao San could make Trekker's liver worse? Would it be indicated to add Chu Shi Wei Ling Tang now, or something else? Thanks in advance.
Janet
by naturevet
December 9, 2014
Hi Janet,

A worsening on the XYS together with the pruritis suggest we need a decongesting type of treatment like Si Miao San or Xiao Chai Hu Tang or both. That's what I would try next. Hang in there. There is sometimes a trial and error process involved in figuring out the best approach to liver disease. The very high ALP and GGT in relation to the ALT suggests this next approach should work

Thank you for updating the case database, too

Steve
by jlrenton@shaw.ca
December 12, 2014
Thank you Steve.
Should I discontinue the Xiao Yao San? Despite the changes on paper, Trekker is feeling well, holding weight and energetic.
Thanks again.
Janet
by naturevet
December 24, 2014
Hi Janet,

If you've seen symptom improvements on Xiao Yao San, then you can start by just reducing the dose

Otherwise, if there are no appreciable changes for the better, I think you can just discontinue it

Steve
by naturevet
December 24, 2014
It might signify some discomfort of the costal arch and the surrounding area. In that case, Xiao Chai Hu Tang would be indicated.

Steve
by jlrenton@shaw.ca
January 2, 2015
Thank you, Steve.
I have discontinued the Xiao Yao San and started the Si Miao San. Clinically Trekker is doing well. He has always been anxious and hyperactive, and this seems to have increased somewhat. Otherwise, without the blood work it would appear that he is almost normal.
I will let you know how he is doing; perhaps if there is no change, I will add the Xiao Chai Hu Tang.
I trust you have had a wonderful Christmas!
Janet
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