Colitis With Anemia And Elevated Liver Enzymes In A Dog
Hi Steve, I’ve started seeing a 4yr M(N) Mastiff that had bloody diarrhea starting in Mar./18 unresponsive to metronidazole, Tylan,salazoprin, Baytril. Improved on high dose prednisone but continued having watery diarrhea. Endoscopy and biopsies diagnosed plasmocytic Colitis. Several diet changes were also tried and diarrhea improved on hypoallergenic dry. Any reduction in Pred dose diarrhea recurred. Dog did not tolerate pred well, severely PU/PD with episodes of incontinence so about 6 weeks ago rDVM reduced pred dose and added Chlorambucil. Over 3 1/2 months dog lost about 30 lbs. When rescued 3 years ago this dog was significantly overweight but owners had gradually got him down to 156lb which he had stayed at for the 2 years prior to the onset of diarrhea. No digestion issues previously. Did have a Hx of hot spots and otitis. When I first saw him he was emaciated, haircoat a bit dry, waxy ears, bilateral mucoid ocular discharge. Ravenous appetite, gets them up at 4:30-5 am for breakfast, sleeps deeply, snores some, dreams some but not a lot. Tends to be a “hot” dog but will go lie in the sun sometimes. Drinking a lot, large vol med yellow urine.Sometimes mucous and undigested food in stool.Tongue sl. pale pink, moist sl. froth. Not a droopy dog. Pulse superficial, sl weak, sl thin, sometimes slippery other times sl wiry.Bloodwork Alk Phos 3454, GGT increased a bit, ALT 458 SDH 62. MCH was sl low but WBC, RBC and HCT normal. With the dependence on pred but poor tolerance of it, Hx of overweight, otitis, hot spots, mucous in stool, mucoid ocular discharge, superficial sometimes slippery pulse, summertime and very high Alk Phos I started him on Si Miao San very gradually, slowly added probiotics intending to introduce digestive enzymes as tolerated and colostrum. Recommended weaning off Chlorambucil and repeating bloodwork and trying to work to a novel protein homemade diet. I wondered if prolonged Damp Heat had damaged Yin and Blood. Dog seemed to do well, no diarrhea, better energy, eating very well but not getting them up as early, haircoat shiny.Started to put back on a bit of weight. Pulse less superficial more moderate still sl slippery / wiry. rDVM gradually reducing pred to 12.5 mg SID Chlorambucil down to 2 mg SID Owners have gone back to Ontario for several weeks. Repeated bloodwork at rDVM this week showed RBC 4.41, ret 0.3% HCT down to 0.29 WBC # normal but lymphocyte sl low. Alk Phos 1988 ALT 343 Alb 30. He is more hungry again, lost 3 precious pounds again but stools and energy good.. Where to go from here? rDVM has dropped pred to 5 mg and Chlorambucil to 2mg EOD.Add Dang Gui to SMS if diarrhea doesn’t recurr?XCHT with SMS+/- DG ? Have recommended milk thistle .Had been thinking steroid hepatopathy and acute inflammation/ congestion but are we now seeing immune mediated issues as the immunosuppressants are reduced. Your thoughts would be very much appreciated. Thanks again, Llewanda