Question Details
Chronic Watery Diarrhea In A Dog
by CorinneC - October 31, 2020    View Case Report
Bruce is a 5yo MN Rottweiler originally from the Middle East. He had two bouts of diarrhea last year that quickly resolved with Metronidazole and Prednisone. However, 8 months ago he had a 3rd bout of diarrhea that did not clear and he has now been diagnosed with lymphocytic-plasmacytic enteritis. He is on Budesonide, Omeprazole, Vit B12, Denamarin, Cerenia, Dexamethasone injections SID through the Internal Medicine specialist. He can only be fed Purina HA vegetarian kibble but doesn't want to eat it! THe owner has tried many homecooked options but he either stops eating them or his diarrhea gets worse. He literally has water for stool.

When I saw him he looked like a rack of bones, no muscle, so thin, BCS 2.5/9, MCS 2/5. His pulses are narrow, superficial, wiry thin. His tongue is lavender-pink, thin, with a reddish tip and thin layer of phlegm at the tip. He has a non-regenerative anemia and elevated ALT, ALKP, GGT, and low cholesterol. Historically low Cobalamin, elevated folate. Also when he was scoped and biopsied they found sock material in his gut!

I started him on Wei Ling Tang and Yi Guan Jian thinking he was SP Qi def + Damp, Liver Blood and Yin def. I saw him yesterday and he is no better :( I am very concerned about his cachexia. I have instructed the owner to try cooked beef to get some protein in if possible, did AQ, and started him on Liu Jun Zi Tang.

I really want to help this boy!!! Please guide me!!!
Replies
by naturevet
November 2, 2020
Hi Corinne,

It may be a continued case of trial and error here, but I like your general strategy of doing something for the Spleen and something for Liver Blood. Xiao Yao San is a possibility, but I would also wonder about Bu Zhong Yi Qi Tang, particularly when the problem began in February (I assume), which is the tail end of the season of Jue Yin excess. This disorder is associated with Stasis in the lower burner leading potentially to intractable diarrhea.

Lymphocytic Plasmacytic inflammation sometimes does not indicate immune mediated disease but just a failure of inflammation to resolve. Boosting circulation through the mucosa is called for to actively resolve inflammation. The drugs he is on tend to do the opposite.

The ginseng in the formula can boost his appetite, and the local immunological effects can counteract any role of immune suppression in propagating a dysbiosis (and secondary IBD).

Even if it doesn't resolve things, I feel like it should at least improve them, so let's give BZYQT a try

Please let us know how it goes!

Steve
by CorinneC
November 11, 2020
Hi Steve,

I have always associated BZYQT with more constipation and decreased peripheral circulation. I guess I'm still confused with this, but I am excited to start it with Bruce Wayne. Do you think I could stop one of the steroids? I hate that he is on all of these drugs! I remember from your recent Liver webinar you talking about the Ice Pack vs Hot Tub phase of inflammation and how any lymphocytic-plasmacytic condition is usually mismanaged with steroids. Can you remind me of why that is?
by naturevet
November 11, 2020
Hi Corinne

You're absolutely correct in your assessment of BZYQT. That it can also deal with the opposite situation - diarrhea - tells us that it is a Harmonizing formula, which was a term only used in Chinese medical works for a formula that deals with opposites.

From a physiological perspective, it addresses the Liver Qi stagnation and Blood deficiency that creates constipation; yet it raises the Spleen Qi to address diarrhea.

My approach to medications is to go beyond what they are accomplishing by introducing a herbal formula, and only once that has been achieved, begin reducing drug doses. That way, I can avoid ripping the rug out from under a patient by removing the drugs, if my herbs meanwhile turn out to be not effective.

Regarding lymphocytic-plasmacytic inflammation, the assumption that most veterinarians make is that they must be dealing with an immune mediated condition. Note however, that lymphocytes and plasmacytes predominate in any inflammatory process that fails to actively resolve. It is the cell population correlated with subacute inflammation. For subacute inflammation to progress through the process of 'active resolution', certain cyokines need to be elaborated. All acute acting anti-inflammatories suppress the production of those cytokines, stopping active resolution from occurring. The patient stays in a perpetual state of subacute inflammation as a result.

The cytokines and steps involved in active resolution have been known for decades but despite all that research, no drugs have been successfully developed to push the process forward. It has been discovered, however, that the promotion of active resolution is a big reason why alternative therapies work so well, explaining their popularity. They are filling a pharmaceutical void. Cardiovascular disease is the top disease of concern relating to the failure of active resolution, so it dominates the articles published. Note, however, that the inflammatory processes involve affect all tissues

Hopefully this clarifies things for you

Steve
by CorinneC
November 20, 2020
Yes, thank you Steve! I actually had Bruce Wayne come in 3 weeks ago worse than ever. Between myself and his rDVM we are gradually weaning him off his medications and I added Liu Jun Zi Tang. He came in yesterday, had GAINED WEIGHT, looked so much brighter and had SOLID STOOL!!!!!!!!!!!!!

I've advised the owner start the Bu Zhong Yi Qi Tang in 1-2 weeks once we are sure he is stable. The owner is afraid to test his situation just yet and I am being patient!
by CorinneC
November 20, 2020
I started patient on Liu Jun Zi Tang 2 weeks ago because he was cachexic, depressed, watery diarrhea worse than ever, and so thin. His rDVM and I decided he should start to slowly wean off all his meds over the next 2 months, except for the Vit B12 and transition him to Digestive Care kibble and chicken livers. He came in today brighter, tail-wagging, solid stool, increase in weight!!
by naturevet
November 20, 2020
Holy cow that is awesome!!!! You rock, Corinne!
by CorinneC
January 9, 2021
I recommended the owners run bloodwork and he still has a moderately regenerative anemia but all else is WNL. He has a good appetite but it can decline when his diarrhea is bad. There is no vomiting or nausea, just borborygmi. I advised they retry the Bu Zhong Yi Qi Tang you advised but in very tiny amounts to start and we will see how this goes. This is a very baffling case!
Reply to this question.
You must be logged in to reply